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Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
Stereotactic radiosurgery for convexity meningiomas
Douglas Kondziolka1, Ricky Madhok, L Dade Lunsford
1Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA. kondziolkads@upmc.edu
Journal of Neurosurgery
|February 10, 2009
Summary
Stereotactic radiosurgery effectively controls convexity meningiomas, offering a valuable treatment option for patients unsuitable for surgery. This method demonstrates high tumor control rates, particularly for benign tumors, with manageable side effects.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Oncology
Background:
- Cerebral convexity meningiomas are often surgically curable.
- Stereotactic radiosurgery (SRS) is a key treatment for intracranial meningiomas.
Purpose of the Study:
- To evaluate clinical and imaging outcomes in patients with convexity meningiomas treated with SRS.
- To assess the efficacy of SRS as a primary or adjuvant therapy.
Main Methods:
- A cohort of 125 patients with convexity meningiomas treated with SRS over 18 years was analyzed.
- Tumor locations included frontal, parietal, temporal, and occipital regions.
- Radiosurgery was performed using the Leksell Gamma Knife with a mean tumor margin dose of 14.2 Gy.
Main Results:
- Tumor control rates were 92% after primary SRS and 97% for Grade I tumors after adjuvant SRS.
- Actuarial tumor control at 3 and 5 years was 86.1% and 71.6%, respectively.
- Overall morbidity was 9.6%, with symptomatic adverse radiation effects in 5%.
Conclusions:
- SRS offers satisfactory tumor control for convexity meningiomas, as an alternative or adjuvant to resection.
- It is particularly valuable for benign meningiomas and patients with tumors in critical neurological regions or those unfit for surgery.
- Morbidity is associated with brain location and tumor volume.
