Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clostridium difficile in inflammatory bowel disease relapse.

J D Gryboski1

  • 1Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06510.

Journal of Pediatric Gastroenterology and Nutrition
|July 1, 1991
PubMed
Summary

Clostridium difficile toxin was found in 16% of inflammatory bowel disease patients during symptom exacerbation. Toxin elimination correlated with symptom resolution after treatment, highlighting its role in disease flares.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Shwachman Award acceptance.

Journal of pediatric gastroenterology and nutrition·1997
Same author

Pancreas divisum in a family with hereditary pancreatitis.

Journal of clinical gastroenterology·1996
Same author

Immunoglobulin studies in children with inflammatory bowel disease.

Annals of allergy·1994
Same author

Crohn's disease in children 10 years old and younger: comparison with ulcerative colitis.

Journal of pediatric gastroenterology and nutrition·1994
Same author

Ulcerative colitis in children 10 years old or younger.

Journal of pediatric gastroenterology and nutrition·1993
Same author

Eating disorders in inflammatory bowel disease.

The American journal of gastroenterology·1993

Area of Science:

  • Gastroenterology
  • Microbiology
  • Infectious Diseases

Background:

  • Inflammatory bowel disease (IBD) encompasses chronic conditions like Crohn's disease and ulcerative colitis.
  • Exacerbations of IBD can be triggered by various factors, including infections.
  • Clostridium difficile infection (CDI) is a known cause of infectious colitis.

Purpose of the Study:

  • To investigate the prevalence of Clostridium difficile toxin in patients experiencing IBD symptom flares.
  • To assess the correlation between C. difficile toxin presence and symptom severity in IBD patients.
  • To evaluate the impact of C. difficile toxin elimination on IBD exacerbation outcomes.

Main Methods:

  • Stool samples were collected from 65 patients with active inflammatory bowel disease exacerbations.

Related Experiment Videos

  • Samples were tested for enteric pathogens, with a specific focus on detecting Clostridium difficile toxin.
  • Patient symptoms were monitored before and after targeted therapy.

    • Main Results:

    • Clostridium difficile toxin was detected in the stool of 10 out of 65 patients (16%).
    • All patients who received therapy showed clearance of their symptoms.
    • A significant correlation was observed between the elimination of C. difficile toxin and the improvement of clinical symptoms.

    Conclusions:

    • Clostridium difficile may play a significant role in triggering or exacerbating inflammatory bowel disease symptoms.
    • Detection and treatment of C. difficile infection can be crucial for managing IBD flares.
    • Further research is warranted to elucidate the precise mechanisms linking C. difficile to IBD exacerbations.