Related Experiment Videos
Chorioretinal lacuna in the amniotic band syndrome
K Hashemi1, E I Traboulsi, R Chavis
1Center for Sight, Georgetown University Medical Center, Washington, DC.
Insights
Amniotic band syndrome (ABS) causes fetal malformations. This study details a rare case of ABS with a unique ocular defect and central nervous system abnormalities, expanding understanding of this condition.
Area of Science:
- Developmental biology
- Medical genetics
- Ophthalmology
Background:
- Amniotic band syndrome (ABS) results from fetal entrapment by amniotic bands.
- Common ABS manifestations include limb malformations and craniofacial defects.
- Ocular defects in ABS are typically corneal leukomas, lid colobomas, strabismus, hypertelorism, and microphthalmos.
Abstract:
The malformations in the amniotic band syndrome (ABS) are due to entrapment of fetal parts by fibrous band in the amniotic sac. Limbs are most commonly affected followed by craniofacial defects in one third of patients. Ocular defects include corneal leukomas and lid colobomas often contiguous with facial clefts, strabismus, hypertelorism, and microphthalmos. Unilateral chorioretinal defects or lacunae are rare findings in the ABS. We report a female infant with such a lacunar defect along with central nervous abnormalities, and discuss the differential diagnosis and the embryopathic implications.