Related Experiment Video
Updated: Jun 25, 2026

Biofunctionalization of Magnetic Nanomaterials
Published on: July 16, 2020
Biomimetic nanowire coatings for next generation adhesive drug delivery systems
Kathleen E Fischer1, Benjamin J Alemán, Sarah L Tao
1Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94158, USA. kayte@berkeley.edu
Abstract:
Without bioadhesive delivery devices, complex compounds are typically degraded or cleared from mucosal tissues by the mucous layer.While some chemically modified, microstructured surfaces have been studied in aqueous environments,adhesion due to geometry alone has not been investigated. Silicon nanowire-coated beads show significantly better adhesion than those with targeting agents under shear, and can increase the lift-off force 100-fold. We have shown that nanowire coatings, paired with epithelial physiology, significantly increase adhesion in mucosal conditions.
Related Concept Videos
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Modified-Release Drug Delivery Systems: Stimuli-Activated
Modified-Release Drug Delivery Systems: Site-Targeted
Drug Delivery Systems: Different Types
Oral Drug Delivery Systems: Introduction
Modified-Release Drug Delivery Systems: Classification

