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Updated: Jun 25, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Diterpene formamides from the tropical marine sponge Cymbastela hooperi and their antimalarial activity in vitro
Anthony D Wright1, Naomi Lang-Unnasch
1College of Pharmacy, University of Hawaii at Hilo, Hilo, Hawaii 96720, USA. adwright@hawaii.edu
Abstract:
Further investigations of the VLC (vacuum-liquid chromatography) fractions obtained from the dichloromethane solubles of the tropical marine sponge Cymbastela hooperi led to the isolation and characterization of five new diterpene formamides, 1-5. Compound 1 is one of the very few examples of a natural product that contains both formamide and isonitrile functionalities within the same molecule. In in vitro antiplasmodial bioassays, 1 was found to have moderate activity (IC(50) 0.5 microg/mL), 2 had weak activity (IC(50) 14.8 microg/mL), and 3-5 were inactive. The pattern of activity found for the metabolites investigated in the current study is consistent with previous findings for these classes of molecules.
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