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Updated: Jun 25, 2026

In Situ SIMS and IR Spectroscopy of Well-defined Surfaces Prepared by Soft Landing of Mass-selected Ions
Published on: June 16, 2014
Aspects of the role of surfaces in ionization processes
1CNR-ISTM, Corso Stati Uniti 4, 35100 Padova, Italy.
Abstract:
The operating principles and some applications of atmospheric pressure desorption electrospray ionization (DESI) and surface activated chemical ionization (SACI) methods are described in detail. The former technique allows one to obtain information on the chemical composition (in terms of organic compounds) present on a surface of interest. The latter, SACI, provides chemical information as a result of the interaction of a vaporised solution of the analyte with a metallic surface. Both techniques typically lead to the production of abundant protonated molecules. The data available in the literature indicate that both DESI and SACI are highly promising techniques with the former giving to mass spectrometry new application fields, and the latter an increasing sensitivity and a lowering of chemical noise that, in the case of biological samples, represent a weak point in many analytical measurements.
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