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Related Experiment Video

Updated: Jun 25, 2026

Whole Vitreous Humor Dissection for Vitreodynamic Analysis
04:41

Whole Vitreous Humor Dissection for Vitreodynamic Analysis

Published on: May 24, 2015

Enzymatic vitreolysis.

Fernando Lopez-Lopez1, Maria Rodriguez-Blanco, Francisco Gómez-Ulla

  • 1Department of Ophthalmology, Complejo Hospitalario Universitario de Santiago de Compostela, Spain. ferloplop@gmail.com

Current Diabetes Reviews
|February 10, 2009
PubMed
Summary
This summary is machine-generated.

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Pharmacologic vitreolysis aims to induce posterior vitreous detachment, improving outcomes for diabetic retinopathy. Novel agents like plasmin show promise in clinical trials for diabetic macular edema and proliferative diabetic retinopathy.

Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Pharmacology

Background:

  • The vitreoretinal junction is implicated in diabetic retinopathy and diabetic macular edema.
  • Vitrectomy improves visual acuity and reduces edema in diabetic patients.
  • Current treatments aim to induce posterior vitreous detachment (PVD) to aid vitrectomy.

Purpose of the Study:

  • To review pharmacologic vitreolysis and posterior vitreous detachment (PVD) studies.
  • To discuss ongoing clinical trials for novel PVD-inducing therapies.
  • To evaluate the efficacy and safety of these agents for diabetic retinopathy.

Main Methods:

  • Review of existing literature on pharmacologic vitreolysis.
  • Analysis of studies investigating agents like plasmin and microplasmin.

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Dissection of Human Vitreous Body Elements for Proteomic Analysis

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Evisceration of Mouse Vitreous and Retina for Proteomic Analyses
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Evisceration of Mouse Vitreous and Retina for Proteomic Analyses

Published on: April 3, 2011

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Last Updated: Jun 25, 2026

Whole Vitreous Humor Dissection for Vitreodynamic Analysis
04:41

Whole Vitreous Humor Dissection for Vitreodynamic Analysis

Published on: May 24, 2015

Dissection of Human Vitreous Body Elements for Proteomic Analysis
05:05

Dissection of Human Vitreous Body Elements for Proteomic Analysis

Published on: January 23, 2011

Evisceration of Mouse Vitreous and Retina for Proteomic Analyses
02:39

Evisceration of Mouse Vitreous and Retina for Proteomic Analyses

Published on: April 3, 2011

  • Description of current clinical trial designs for novel therapies.

    • Main Results:

    • Pharmacologic agents are being developed to induce PVD.
    • Plasmin and microplasmin have demonstrated PVD induction via intravitreal injection.
    • Clinical trials are underway to assess safety and efficacy.

    Conclusions:

    • Pharmacologic vitreolysis offers a potential new therapeutic avenue for diabetic retinopathy.
    • Novel agents may facilitate vitrectomy and reduce complications.
    • Ongoing trials will clarify the role of these therapies in managing diabetic eye disease.