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Anti-CD3 recombinant diphtheria immunotoxin therapy of cutaneous T cell lymphoma

A E Frankel1, S L Zuckero, A A Mankin

  • 1Scott & White Cancer Research Institute, 5701 S. Airport Road, Temple, TX 76502, USA. afrankel@swmail.sw.org

Current Drug Targets
|February 10, 2009
PubMed

The recombinant CD3 immunotoxin, A-dmDT(390)-bisFv(UCHT1), composed of the catalytic and translocation domains of diphtheria toxin fused to two single chain Fv fragments of an anti-CD3epsilon monoclonal antibody was administered to five patients with cutaneous T cell lymphoma (CTCL) by eight 15 min intravenous infusions over four days. Side effects were fever, chills, nausea, hypoalbuminemia, transaminasemia and reactivation of EBV and CMV. Half-life of drug was 40 min. Anti-immunotoxin antibodies developed in all patients after two weeks. Two patients had partial remissions lasting 1 and 6+ months. The agent is undergoing further dose escalation and shows promising results in this disease.

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