Related Experiment Video
Updated: Jun 25, 2026
05:34
Operating and Biocontainment Procedures of a Facility for Laboratory Mice with a Natural Microbiome: Immunophenotyping Procedure
Published on: December 13, 2024
The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models
H Fuchs1, V Gailus-Durner, T Adler
1Inst. of Exp. Genetics, Helmholtz Zentrum München, German Res. Center for Environ. Health, Munich/Neuherberg, Germany.
Current Pharmaceutical Biotechnology
|February 10, 2009
Summary
The German Mouse Clinic (GMC) provides comprehensive phenotyping for mouse models, revealing novel phenotypes and aiding human disease association. Future work includes environmental challenge tests for genome-environment interactions.
Area of Science:
- Genetics
- Phenomics
- Translational Medicine
Background:
- The German Mouse Clinic (GMC) is a large-scale phenotyping center.
- It analyzes mouse mutant lines using standardized, comprehensive methods for a systemic view of phenotypes.
Purpose of the Study:
- To conduct comprehensive phenotyping of mouse mutant lines.
- To identify novel phenotypes and their association with human diseases.
- To establish a platform for studying genome-environmental interactions.
Main Methods:
- Systematic phenotyping across 16 areas including allergy, behavior, metabolism, and pathology.
- Analysis of over 80 mutant lines for 320 parameters.
- Development of environmental challenge tests for nutrition, exercise, air, stress, and infection.
Main Results:
- 95% of analyzed mutant lines exhibited new or additional phenotypes.
- Data contributed to associating mouse lines with corresponding human diseases.
- Systemic analysis revealed pleiotropic gene functions and refined characterizations.
Conclusions:
- Comprehensive phenotyping at GMC is crucial for understanding gene function and disease mechanisms.
- The clinic serves as an open-access platform for collaborative research.
- Future environmental challenge tests will identify genetic predispositions to environmental factors.
Related Concept Videos
02:43Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
02:43Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...