Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
Long-term Depression01:03

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcriptional profiles of immature neurons in aged human hippocampus track Alzheimer's pathology and cognitive resilience.

Cell stem cell·2026
Same author

Hallmarks of healthy cognitive aging: Inter-individual differences in aging trajectories.

Ageing research reviews·2026
Same author

Adult neurogenesis: New neurons, new opportunities.

Cell stem cell·2026
Same author

microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer's disease patients.

Acta neuropathologica communications·2026
Same author

Doublecortin-like knockdown in mice attenuates obesity by stimulating energy expenditure in adipose tissue.

Scientific reports·2024
Same author

The 'middle-aging' brain.

Trends in neurosciences·2024

Related Experiment Video

Updated: Jun 25, 2026

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice
05:28

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice

Published on: May 15, 2019

Antiglucocorticoids, neurogenesis and depression.

Carlos P Fitzsimons1, Lenneke W A van Hooijdonk, John A Morrow

  • 1LACDR/Medical Pharmacology Department, Leiden University, Gorlaeus Laboratory, Einsteinweg 55, 2333CC Leiden, The Netherlands.

Mini Reviews in Medicinal Chemistry
|February 10, 2009
PubMed
Summary

Antiglucocorticoids may treat depression by enhancing hippocampal neurogenesis, similar to antidepressants. This review explores therapeutic strategies targeting glucocorticoid receptors and doublecortin-like kinase for depression.

More Related Videos

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice
07:13

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

Published on: October 24, 2018

Related Experiment Videos

Last Updated: Jun 25, 2026

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice
05:28

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice

Published on: May 15, 2019

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice
07:13

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

Published on: October 24, 2018

Area of Science:

  • Neuroscience
  • Pharmacology
  • Cell Biology

Background:

  • Depression is linked to impaired hippocampal neurogenesis.
  • Antiglucocorticoids show potential antidepressant effects.
  • Conventional antidepressants may also boost neurogenesis.

Purpose of the Study:

  • To explore antiglucocorticoid-based therapeutic strategies for depression.
  • To review glucocorticoid receptor antagonist interactions.
  • To discuss doublecortin-like kinase as a novel therapeutic target.

Main Methods:

  • Literature review of antiglucocorticoid mechanisms.
  • Analysis of glucocorticoid receptor and antagonist interactions.
  • Exploration of doublecortin-like kinase in neurogenesis regulation.

Main Results:

  • Antiglucocorticoids may offer a novel approach to depression treatment.
  • Glucocorticoid receptor modulation is a key mechanism.
  • Doublecortin-like kinase regulates glucocorticoid signaling in neuronal progenitors.

Conclusions:

  • Antiglucocorticoid therapies hold promise for treating depressive symptoms.
  • Targeting glucocorticoid signaling pathways presents new avenues for antidepressant development.
  • Doublecortin-like kinase represents a potential target for enhancing neurogenesis in depression.