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Clinical relevance of myocardial bridging severity: single center experience

F Mookadam1, J Green, D Holmes

  • 1Mayo Clinic, Scottsdale, AZ, USA. mookadam.farouk@mayo.edu

European Journal of Clinical Investigation
|February 10, 2009
PubMed

Insights

Myocardial bridging, a condition where coronary arteries are compressed, is linked to angina and myocardial infarction, especially with severe compression. This suggests it is not a benign anatomical variation and may promote plaque buildup.

Area of Science:

  • Cardiology
  • Vascular Biology

Background:

  • Myocardial bridging involves systolic compression of epicardial coronary arteries.
  • Its clinical significance in non-obstructive coronary artery disease requires further investigation.

Purpose of the Study:

  • To assess the clinical significance of myocardial bridging.
  • To evaluate the clinical presentation in patients with non-obstructive coronary artery disease and myocardial bridging.

Main Methods:

  • Retrospective review of 14,416 coronary angiography reports (Sept 2002 - Mar 2005).
  • Included 226 patients with isolated myocardial bridging and <50% stenosis in non-bridged arteries.
  • Classified bridging severity: Group I (<50%), Group II (50-70%), Group III (>or=70% systolic compression).

Main Results:

  • Left anterior descending artery was the most common site (93%).
  • Significant difference in non-fatal myocardial infarction between Group I and Group III (P=0.02).
  • Unstable angina showed the highest association with myocardial bridging, though severity did not correlate significantly.

Conclusions:

  • Myocardial bridging is not a benign anatomical variation.
  • Associated with angina and myocardial infarction in patients with >or=70% systolic compression.
  • The bridged segment may contribute to enhanced atherosclerotic plaque formation.
Abstract

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