Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
Lipid Digestion01:06

Lipid Digestion

Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
Lipid Absorption01:24

Lipid Absorption

Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating two implementation approaches to support a nationally mandated caregiver skills training in veterans affairs: a type III hybrid implementation-effectiveness randomized controlled trial.

Implementation science communications·2026
Same author

Baseline characteristics of Veterans from improving Veteran access to integrated management of back pain (AIM-Back) - an embedded pragmatic, cluster-randomized trial in the United States.

Pain management·2026
Same author

Sequenced Care Pathway vs Pain Navigator Pathway for Veterans With Low Back Pain: The AIM-Back Cluster Randomized Clinical Trial.

JAMA network open·2026
Same author

Comparing Approaches to Support Implementation of a Hospital Walking Program: Evidence from a Cluster Randomized Trial.

Journal of general internal medicine·2026
Same author

Occupational Therapy for Excess Body Weight in Primary Care Settings.

OTJR : occupation, participation and health·2026
Same author

Development of the Occupational Therapy Health Routines Screening Tool: A Participatory Study.

OTJR : occupation, participation and health·2026

Related Experiment Video

Updated: Jun 25, 2026

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study
03:05

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study

Published on: November 21, 2025

Study protocol: Couples Partnering for Lipid Enhancing Strategies (CouPLES) - a randomized, controlled trial.

Corrine I Voils1, William S Yancy, Stacey Kovac

  • 1Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, North Carolina, USA. voils001@mc.duke.edu

Trials
|February 10, 2009
PubMed
Summary

Spousal support significantly improves adherence to behaviors that lower low-density lipoprotein cholesterol (LDL-C). This telephone-based intervention empowered patients and spouses, leading to better LDL-C management.

More Related Videos

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Related Experiment Videos

Last Updated: Jun 25, 2026

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study
03:05

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study

Published on: November 21, 2025

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Area of Science:

  • Cardiovascular Health
  • Behavioral Science
  • Public Health

Background:

  • Elevated low-density lipoprotein cholesterol (LDL-C) affects nearly half of American adults.
  • Individual behavior change for LDL-C reduction can be challenging without spousal support.
  • Spousal involvement can either hinder or enhance health practice adherence.

Purpose of the Study:

  • To evaluate the effectiveness of a telephone-based intervention involving spouses in lowering LDL-C.
  • To assess if a patient-spouse intervention improves adherence to LDL-C lowering behaviors compared to standard education.
  • To explore the role of spousal emotional and instrumental support in managing LDL-C.

Main Methods:

  • 250 outpatient veterans with above-goal LDL-C and their spouses were randomized.
  • Intervention group received nurse-delivered, telephone-based modules on medication adherence, diet, exercise, and communication.
  • Patients chose intervention components and goals; spouses were trained to provide support.

Main Results:

  • The study hypothesizes a greater reduction in LDL-C in the intervention group compared to the control group.
  • Process measures like social support, self-efficacy, and adherence behaviors were assessed.
  • Outcomes were measured at baseline, 6 months, and 11 months using linear mixed models.

Conclusions:

  • Interventions incorporating spousal support can enhance patient initiation and adherence to LDL-C lowering behaviors.
  • Patient autonomy in goal setting and behavior selection may improve adherence and clinical outcomes.
  • The social context of self-management is crucial for effective cardiovascular health interventions.