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Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit
Katrin Groebke Zbinden1, Lilli Anselm, David W Banner
1F Hoffmann - La Roche Ltd, Basel, Switzerland. katrin.groebke_zbinden@roche.com
European Journal of Medicinal Chemistry
|February 10, 2009
Abstract:
Starting from a hit identified by focused screening, 3-aminopyrrolidine factor Xa inhibitors were designed. The binding mode as determined by X-ray structural analysis as well as the pharmacokinetic behaviour of selected compounds is discussed.
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