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Related Concept Videos

Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...

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A Culture Method to Maintain Quiescent Human Hematopoietic Stem Cells
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A Culture Method to Maintain Quiescent Human Hematopoietic Stem Cells

Published on: May 17, 2021

The river of stem cells.

Cheng-Ming Chuong1, Randall Bruce Widelitz

  • 1Department of Pathology, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90033, USA. cmchuong@usc.edu

Cell Stem Cell
|February 10, 2009
PubMed
Summary
This summary is machine-generated.

Researchers identified the hair germ as a new intermediate stage during hair regeneration. This finding suggests that stem cell states can be regulated to control the number of intermediate cell stops based on the body's needs.

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Area of Science:

  • Stem cell biology
  • Dermatology
  • Regenerative medicine

Background:

  • The hair follicle undergoes cyclical regeneration, involving complex stem cell dynamics.
  • Understanding the precise lineage progression from stem cells to differentiated cells is crucial for regenerative processes.

Discussion:

  • Greco et al. (2009) identify the hair germ as a distinct intermediate cell state.
  • This novel stop occurs between the established bulge stem cells and transient amplifying cells.
  • The hair germ's characterization provides new insights into the hair follicle stem cell hierarchy.

Key Insights:

  • The hair germ represents a previously unrecognized intermediate cell population in hair regeneration.
  • Stem cell regulation can modulate the number of intermediate cell stages during regeneration.
  • This discovery impacts our understanding of stem cell plasticity and differentiation control.

Outlook:

  • Further research can explore the molecular mechanisms regulating hair germ formation and function.
  • This finding may have implications for therapeutic strategies targeting hair loss and other regenerative disorders.
  • Investigating stem cell state regulation in other regenerative systems could reveal similar intermediate stages.