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Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Vaccinations01:51

Vaccinations

Overview
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

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Related Experiment Video

Updated: Jun 25, 2026

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
10:37

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix

Published on: October 20, 2021

New perspectives for hepatitis B vaccines and immunization.

Maria Rapicetta1, Emilio D'Ugo, Claudio Argentini

  • 1Viral Hepatitis Unit, Department of Infectious, Parasitic and Immune-Mediated Disease, Istituto Superiore di Sanità, Rome, Italy. rapicett@iss.it

Vaccine
|February 10, 2009
PubMed
Summary

New Hepatitis B virus (HBV) vaccine research utilizes a woodchuck model to assess immunogenicity and protection. A novel woodchuck antibody-particle complex effectively inhibited HBV replication, offering a promising therapeutic avenue.

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Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
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Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA

Published on: December 15, 2023

Related Experiment Videos

Last Updated: Jun 25, 2026

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
10:37

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix

Published on: October 20, 2021

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
04:11

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA

Published on: December 15, 2023

Area of Science:

  • Hepatology and Virology
  • Vaccine Development
  • Immunology

Background:

  • Hepatitis B virus (HBV) infection remains a significant global health concern.
  • Current HBV vaccine research focuses on improving antigen composition and adjuvants for enhanced immune responses.
  • Optimizing immunotherapeutic strategies is crucial for effective HBV treatment.

Purpose of the Study:

  • To evaluate the efficacy of a woodchuck hepatitis virus (WHV)/Marmota monax model for assessing novel HBV vaccine formulations for human use.
  • To investigate the immunogenicity and protective activity of specific HBV vaccine candidates.
  • To explore new therapeutic approaches for chronic HBV infection.

Main Methods:

  • Utilized the WHV/Marmota monax model to evaluate vaccine immunogenicity and protection.
  • Administered HBV CHO-PreS/S and adjuvanted S/Core vaccines.
  • Tested a complex of HBV-derived woodchuck PreS/S antibodies coupled with WHV particles.

Main Results:

  • The WHV/Marmota monax model proved applicable for evaluating HBV vaccine formulations.
  • The WHV-derived woodchuck PreS/S antibody-WHV particle complex demonstrated the ability to inhibit viral replication.
  • Evaluated protective activity of specific vaccine candidates.

Conclusions:

  • The WHV/Marmota monax model is a viable platform for preclinical HBV vaccine evaluation.
  • A novel antibody-particle complex shows potential for inhibiting HBV replication.
  • Future research should explore combination therapies including antivirals, vaccines, and immunomodulators for chronic HBV infection.