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Updated: Jun 25, 2026
Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
Published on: October 22, 2020
Induction of early decidualization by cadmium, a major contaminant of cigarette smoke
Ryo Tsutsumi1, Hisahiko Hiroi, Mikio Momoeda
1Department of Obstetrics and Gynecology, the University of Tokyo, Tokyo, Japan.
Abstract:
To investigate the effect of cadmium (Cd) contamination on endometrial function, human endometrial stromal cells were isolated and cultured with E(2) plus P in the presence of Cd, a major contaminant in cigarette smoke, and assayed for PRL concentrations and its messenger RNA expression. Cd significantly increased PRL concentrations in the culture media and significantly up-regulated PRL messenger RNA expression of the endometrial stromal cells, suggesting that Cd stimulates decidualization of the endometrium and may disrupt endometrial environment, causing early decidualization.
