Related Experiment Video
Updated: Jun 25, 2026
Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens
Published on: May 23, 2014
Endometrial effects of a single early luteal dose of the selective progesterone receptor modulator CDB-2914
Pamela Stratton1, Eric D Levens, Beth Hartog
1Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892-1109, USA.
Objective:
To test potential contraceptive mechanisms of the selective P receptor modulator CDB-2914 in the early luteal phase.
Design:
Prospective randomized clinical trial.
Setting:
Clinical research center.
Patient(S):
Fifty-six women with regular cycles.
Intervention(S):
Women received a single dose of CDB-2914 (10, 50, or 100 mg) or placebo given after ovulation and within 2 days of the LH surge. Four to 6 days later, a transvaginal ultrasound scan measured endometrial thickness, and an endometrial biopsy specimen was obtained.
Main Outcome Measure(S):
The endometrium was evaluated by thickness and by immunohistochemical analysis for P-dependent markers; safety laboratory tests were performed, and E(2) and P levels were obtained.
Result(S):
CDB-2914 caused a significant dose-dependent decrease in endometrial thickness, an increase in glandular P receptors, and a decrease in peripheral node addressins. Estradiol and P levels and menstrual cycle timing were not altered. No adverse effects were observed.
Conclusion(S):
The alteration in endometrial thickness and P-dependent markers of implantation in the absence of changes in hormone levels and cycle length suggests that CDB-2914 may have contraceptive properties.
Related Concept Videos
01:27Ovarian Cycle
01:22Hormonal Regulation of the Menstrual Cycle
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
01:21Intrauterine Drug Delivery Systems