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Updated: Jun 25, 2026

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
Published on: September 12, 2016
[Crohn's disease during the course of multiple sclerosis: role of interferon-beta therapy]
1Service de médecine interne et maladies systémiques, CHU de Dijon, hôpital Général, 3, rue du Faubourg-Raines, 21000 Dijon, France. samsonmaxime@gmail.com
Abstract:
Interferon-beta (IFN-beta) therapy can trigger immune adverse effects. We report a patient, who was treated for multiple sclerosis (MS) by IFN-beta during 3 years before developing a severe colitis due to Crohn's disease (CD). Neurological manifestations may occur in CD but rarely mimic MS. This report's points highlight the possible association of MS and CD, where IFN-beta therapy probably unmasked CD. Indeed, similar cases of CD flares have been reported after IFN-alpha therapy for chronic C hepatitis.
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