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Published on: May 9, 2019
Neural functional organization of hallucinations in schizophrenia: multisensory dissolution of pathological emergence
Renaud Jardri1, Delphine Pins, Maxime Bubrovszky
1Laboratoire de Neurosciences Fonctionnelles et Pathologies, CNRS UMR-8160, Hôpital Roger Salengro, Université Lille Nord de France, Centre Hospitalier Universitaire de Lille, 59037 Lille cedex, France. r-jardri@chru-lille.fr
Abstract:
Although complex hallucinations are extremely vivid, painful symptoms in schizophrenia, little is known about the underlying mechanisms of multisensory integration in such a phenomenon. We investigated the neural basis of these altered states of consciousness in a patient with schizophrenia, by combining state of the art neuroscientific exploratory methods like functional MRI, diffusion tensor imaging, cortical thickness analysis, electrical source reconstruction and trans-cranial magnetic stimulation. The results shed light on the functional architecture of the hallucinatory processes, in which unimodal information from different modalities is strongly functionally connected to higher-order integrative areas.
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