Related Experiment Video
Updated: Jun 25, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Hemostasis during functional endoscopic sinus surgery: the effect of local infiltration with adrenaline
Ta-Jen Lee1, Chi-Che Huang, Po-Hung Chang
1Department of Otolaryngology, Chang Gung Memorial Hospital, Kwei-Shan, Taoyuan, Taiwan.
Objectives:
To determine the feasibility of the use of a topical vasoconstrictor for hemostasis during functional endoscopic sinus surgery.
Study Design:
Case-control study.
Subjects And Methods:
From May 1998 to August 2002, 226 patients (injection group) with bilateral chronic rhinosinusitis received an adrenaline injection for hemostasis during functional endoscopic sinus surgery at our tertiary referral center. After September 2002, topical adrenaline was applied for hemostasis in 226 consecutive patients (noninjection group) who underwent the same surgery. The two groups were matched by age, sex, body weight, stage of chronic rhinosinusitis, and pre-anesthesia blood pressure. The hemostatic effects in each group were analyzed.
Results:
No statistically significant differences in operation time and intraoperative blood loss were reached between the two groups of patients.
Conclusions:
Topical use of adrenaline achieved similar hemostatic effect compared with injection of adrenaline. Intranasal injection of a vasoconstrictor, in consideration of its adverse effects, may be avoided during surgery.
Related Concept Videos
Epistaxis
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
Suctioning the Nasopharyngeal Airway
Equipment Required
Local Anesthetics: Pharmacokinetics
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
One of the advantages of...
Vascular Spasm
Adrenergic Agonists: Therapeutic Uses
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and anaphylaxis:...