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Related Concept Videos

ATP Driven Pumps III: V-type Pumps01:30

ATP Driven Pumps III: V-type Pumps

V-type pumps are ATP-driven pumps found in the vacuolar membranes of plants, yeast, endosomal and lysosomal membranes of animal cells, plasma membranes of a few specialized eukaryotic cells, and some prokaryotes. They are also known as the V1Vo-ATPase, that couple ATP hydrolysis to transport protons against a concentration gradient.
The peripheral or cytosolic V1 domain with eight subunits is involved in ATP hydrolysis. The integral or transmembrane V0 domain containing at least five subunits...
ATP Driven Pumps II: P-type Pumps01:34

ATP Driven Pumps II: P-type Pumps

The P-type pumps are a large family of integral membrane transporter ATPases. They are divided into five major types based on substrate specificity, from I to V.
A typical P-type pump has three cytosolic domains: nucleotide-binding (N), phosphorylation (P), and activator (A) domains. These domains are connected to the membrane-spanning helices by short amino acid segments. ATP hydrolysis and covalent phosphoenzyme intermediate formation are crucial parts of the catalytic cycle. At the highly...

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Related Experiment Video

Updated: Jun 25, 2026

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart
08:49

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

Published on: May 11, 2018

Off-pump replacement of the INCOR implantable axial-flow pump.

Kuniki Nakashima1, Matthias E W Kirsch, Emmanuelle Vermes

  • 1Service de Chirurgie Thoracique et Cardiovasculaire, AP-HP, Hôpital Henri Mondor, Créteil, France. kuniki.nakashima@hmn.aphp.fr

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
|February 10, 2009
PubMed
Summary

Mechanical circulatory support device replacements are increasing. This case study details a successful ventricular assist device (VAD) replacement without cardiopulmonary bypass, highlighting unique system features.

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Last Updated: Jun 25, 2026

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart
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Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

Published on: May 11, 2018

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Published on: February 5, 2021

Area of Science:

  • Cardiovascular Surgery
  • Biomedical Engineering
  • Medical Device Technology

Background:

  • Mechanical circulatory support (MCS) devices, such as ventricular assist devices (VADs), are increasingly used for longer durations.
  • The growing prevalence of VADs necessitates strategies for device longevity and management, including potential replacements.
  • Total or partial replacement of VADs is becoming a more frequent clinical consideration.

Observation:

  • This report details a specific case involving the replacement of an INCOR implantable axial-flow pump.
  • The key observation was the successful explantation and replacement of the VAD without the need for cardiopulmonary bypass (CPB).
  • The INCOR system's design facilitated this off-pump procedure, demonstrating unique operational capabilities.

Findings:

  • The INCOR axial-flow pump was successfully replaced in a patient without utilizing cardiopulmonary bypass.
  • This procedure highlights the feasibility and potential advantages of performing VAD replacement off-pump.
  • The specific features of the INCOR system were crucial in enabling this minimally invasive approach.

Implications:

  • Off-pump VAD replacement may offer benefits such as reduced surgical time and complications.
  • This approach could set a precedent for future VAD replacement surgeries, improving patient outcomes.
  • Further research into the application of this technique with various VAD systems is warranted.