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Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

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Published on: October 10, 2012

Candidate endophenotypes for genetic studies of suicidal behavior.

J John Mann¹, Victoria A Arango, Shelli Avenevoli

¹Department of Psychiatry, NewYork State Psychiatric Institute/ColumbiaUniversity, 1051 Riverside Drive, New York, NY 10032, USA. jjm@columbia.edu

Biological Psychiatry

|February 10, 2009

Summary

Identifying genes linked to suicidal behavior is challenging. Researchers propose using endophenotypes like aggression and early-onset depression to advance genetic studies of suicide risk.

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Area of Science:

Genetics
Psychiatry
Behavioral Science

Background:

Suicide attempts and completed suicide demonstrate significant heritability, established through twin, adoption, and family studies.
Identifying specific genes contributing to suicidal behavior (suicide diathesis) is complex due to the intricate nature of the phenotype and overlap with genes for associated psychiatric disorders like mood disorders.

Framework:

An endophenotype approach is proposed to overcome genetic study challenges.
This involves identifying intermediate phenotypes—biological or behavioral markers—that are heritable and more directly linked to genes.

Implementation:

A workshop involving the American Foundation for Suicide Prevention, Columbia University Psychiatry, and the National Institute of Mental Health identified potential endophenotypes.
Key candidates include trait aggression/impulsivity, early-onset major depression, neurocognitive function, and cortisol social stress response.

Implications:

These identified endophenotypes offer promising targets for future genetic research into suicidal behavior.
Further investigation is warranted for other candidates such as serotonergic neurotransmission, second messenger systems, and borderline personality disorder traits.