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Microfeeding with different ultrasonic nozzle designs.

Xuesong Lu1, Shoufeng Yang, Julian R G Evans

  • 1Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK.

Ultrasonics
|February 10, 2009
PubMed
Summary

Ultrasonic vibration enables precise microfeeding of dry powders for applications like pharmaceutical dosing. Four actuation methods were tested, all achieving powder delivery but with varying flow rates and dose uniformity.

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Area of Science:

  • Engineering
  • Materials Science
  • Physics

Background:

  • Microfeeding of dry powders is crucial for solid freeforming and pharmaceutical applications.
  • Ultrasonic vibration offers a simple yet effective method for actuating microfeeding systems.

Purpose of the Study:

  • To investigate four different ultrasonic actuation configurations for microfeeding dry powder through a glass capillary nozzle.
  • To evaluate the performance characteristics of each configuration, including flow rate and dose uniformity.

Main Methods:

  • Four types of ultrasonic actuation were designed and implemented: Type I (transducer on vessel base), Type II (transducer on vessel sidewall), Type III (direct longitudinal vibration), and Type IV (direct progressive wave vibration).
  • A vertical glass capillary served as the nozzle for powder discharge.
  • High-speed videography was employed to observe particle discharge dynamics.

Main Results:

  • All four investigated configurations successfully achieved dry powder microfeeding and dosing.
  • Significant variations were observed in minimum flow rate, voltage amplitude dependence, and dose uniformity across the different configurations.
  • The characteristics of powder discharge differed considerably between the four types of ultrasonic actuation.

Conclusions:

  • Ultrasonic vibration is a viable method for dry powder microfeeding and dosing with simple equipment.
  • The choice of ultrasonic actuation configuration significantly impacts the performance and precision of the microfeeding system.
  • Further optimization of actuation methods is needed to achieve consistent and uniform powder delivery for specific applications.