Related Experiment Video
Updated: Jun 25, 2026
06:44
Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel
Published on: September 8, 2017
Docetaxel-related side effects and their management
Jackie Baker1, Jaffer Ajani, Florian Scotté
1University of Texas MD Anderson Cancer Center, Gastrointestinal Medical Oncology, Faculty Center, Houston, TX 77030, USA. jsbaker@mdanderson.org
Summary
This review highlights limited research on docetaxel side effects, offering guidelines for febrile neutropenia management. Further research is needed to improve patient care and manage other docetaxel-related adverse events.
Area of Science:
- Oncology
- Pharmacology
- Evidence-based Medicine
Background:
- Docetaxel is a key cancer treatment, but its efficacy is hindered by side effect management challenges.
- Effective management of docetaxel-induced side effects is crucial for optimizing patient outcomes in clinical practice.
Purpose of the Study:
- To review published literature on docetaxel-related side effects.
- To provide evidence-based recommendations for the prevention and management of common docetaxel side effects.
Main Methods:
- Systematic literature search of PubMed, ASCO, and Cochrane Library databases.
- Focused on English articles from the past 5 years (PubMed) and 2 years (ASCO).
- Included six common docetaxel side effects relevant to oncology nurses.
Main Results:
- 103 citations identified; only 14 discussed prevention/management strategies.
- Febrile neutropenia (6), hypersensitivity reactions (3), fluid retention (1), and nail changes (4) were covered.
- No articles found on asthenia or neuropathy; guidelines provided for G-CSF in febrile neutropenia.
Conclusions:
- Limited evidence exists for managing most docetaxel side effects, hindering evidence-based recommendations.
- Authors suggest mild symptom severity and manageable side effects with supportive care.
- Emphasizes the need for further research and shared experiences to enhance patient care standards.
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