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Coronin 1 is essential for IgM-mediated Ca2+ mobilization in B cells but dispensable for the generation of immune
Benoit Combaluzier1, Philipp Mueller, Jan Massner
1Biozentrum, University of Basel, Basel, Switzerland.
Abstract:
Coronin 1 is a leukocyte specific regulator of Ca(2+)-dependent signaling and is essential for the survival of peripheral T lymphocytes, but its role in B cells is unknown. In this study, we show that coronin 1 is essential for intracellular Ca(2+) mobilization and proliferation upon triggering of the BCR. However, the presence of costimulatory signals rendered coronin 1 dispensable for B cell signaling, consistent with the generation of normal immune responses against a variety of Ags in coronin 1-deficient mice. We conclude that coronin 1, while being essential for T cell function and survival, is dispensable for B cell function in vivo.
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