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Kidney Transplant I: Introduction

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

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Updated: Jun 25, 2026

Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP

Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP

Published on: February 14, 2022

Lung transplantation: past, present, and future.

J J Yun¹, D P Mason

¹Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, OH, USA.

Minerva Chirurgica

|February 10, 2009

Summary

Lung transplantation offers a vital treatment for end-stage lung disease. Ongoing advancements aim to improve donor lung availability and reduce rejection, enhancing long-term survival for more patients.

Area of Science:

Pulmonology and Thoracic Surgery
Transplantation Medicine
Immunology

Background:

Lung transplantation (LTx) is a critical intervention for end-stage lung disease (ESLD).
Graft survival is significantly impacted by post-transplant complications, primarily infection and immune rejection.
Bronchiolitis obliterans syndrome (BOS) remains a major cause of graft failure and reduced long-term survival.

Purpose of the Study:

To review current challenges in lung transplantation, focusing on survival limitations.
To highlight emerging techniques aimed at expanding donor lung availability.
To discuss advancements in preventing lung allograft rejection and managing BOS.

Main Methods:

Review of current literature on lung transplantation outcomes and complications.

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Last Updated: Jun 25, 2026

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Analysis of novel strategies for donor lung preservation and augmentation.

Examination of immunomodulatory approaches and therapies targeting BOS.

Main Results:

Infection and rejection, especially BOS, are key determinants of post-LTx survival.
Innovations are emerging to increase the pool of viable donor lungs.
New methods show potential in mitigating immune responses and preventing BOS.

Conclusions:

Lung transplantation remains a life-saving procedure for ESLD patients.
Continuous evolution in LTx techniques promises to improve graft and patient survival.
Future developments are expected to broaden the applicability and success of lung transplantation.