[Impact of Opisthorchis invasion on lipid peroxidation and hemostasis during pregnancy]

Blood cell lipid peroxidation processes and the state of thrombocytic and coagulative hemostasis were studied in 214 pregnant women and parturients with Opisthorchis invasion amongst the indigenous population and newcomers of the Khanty-Mansi Autonomic District-Yugra. Chronic opisthorchiasis was found to enhance lipid peroxidation in the blood cells, to accelerate the activation of thrombocytic and coagulative hemostasis during gestation, at labor, and in the postpartum period. Opisthorchis invasion variously affected the state of lipid peroxidation and hemostasis in the examined groups. In the indigenous women, the number of activated forms of platelets increased, without any obvious change in their functional potential, which was unaccompanied by changes in the parameters of coagulative hemostasis and lipid peroxidation. Increased activation of platelets, their hyperaggregability, and subsequent depletion of their functional potential were revealed in the newcomers. This was attended by hypercoagulation with signs of acceleration of continuous blood coagulation, by enhanced lipid peroxidation and reduced antioxidative potential in the blood cells.