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Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Inflammation01:38

Inflammation

Overview
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Hypodermis01:02

Hypodermis

The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...

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Related Experiment Video

Updated: Jun 25, 2026

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

[Inflammatory changes in obese adipose tissue].

Ayaka Ito1, Takayoshi Suganami, Yoshihiro Ogawa

  • 1Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|February 11, 2009
PubMed
Summary

Obesity causes chronic inflammation, potentially leading to metabolic syndrome. Understanding adipose tissue remodeling phases can reveal therapeutic targets for obesity-related inflammation and metabolic disorders.

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Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry
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Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

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Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry
07:32

Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry

Published on: March 6, 2018

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots
06:50

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

Published on: August 16, 2020

Area of Science:

  • Molecular biology
  • Immunology
  • Metabolic research

Context:

  • Obesity is increasingly recognized as a state of chronic, low-grade inflammation.
  • This inflammation is a potential driver of metabolic derangements associated with obesity.

Purpose:

  • To elucidate the molecular mechanisms driving adipose tissue remodeling during obesity.
  • To identify therapeutic targets for obesity-induced inflammation and metabolic syndrome.

Summary:

  • Adipose tissue remodeling in obesity involves three key phases: adipocyte proliferation/hypertrophy, macrophage infiltration, and adipocyte-macrophage interactions.
  • Investigating the inflammatory molecular mechanisms within each phase is crucial.
  • This approach aims to uncover novel therapeutic strategies.

Impact:

  • Identifying molecular targets could lead to treatments reducing obesity-related inflammation.
  • This may help prevent or manage metabolic syndrome.
  • Advances understanding of the link between obesity, inflammation, and metabolic health.