Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...

Drug Dosing: Obese Patients

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...

Bias in Epidemiological Studies

Bias in Epidemiological Studies

Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cross-sectional association of skeletal muscle mass and strength with dietary habits and physical activity among first-year university students in Japan: Results from the KEIJI-U study.

Nutrition (Burbank, Los Angeles County, Calif.)·2023

Same author

Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers.

Proceedings of the National Academy of Sciences of the United States of America·2022

Same author

C-type natriuretic peptide facilitates autonomic Ca<sup>2+</sup> entry in growth plate chondrocytes for stimulating bone growth.

eLife·2022

Same author

Impaired leptin responsiveness in the nucleus accumbens of leptin-overexpressing transgenic mice with dysregulated sucrose and lipid preference independent of obesity.

Neuroscience research·2021

Same author

NRSF-<i>GNAO1</i> Pathway Contributes to the Regulation of Cardiac Ca<sup>2+</sup> Homeostasis.

Circulation research·2021

Same author

Phase angle from bioelectrical impedance analysis is a useful indicator of muscle quality.

Journal of cachexia, sarcopenia and muscle·2021

Search research articles

Related Experiment Video

Updated: Jun 25, 2026

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

[Obesity in CASE-J Study].

Masakazu Hirata¹, Kouji Oba, Kenji Ueshima

¹Department of Medicine and Medical Science, Kyoto University Graduate School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|February 11, 2009

Summary

This summary is machine-generated.

Obesity and hypertension are linked, with adipose tissue releasing hormones that worsen metabolic and cardiovascular issues. Angiotensin receptor blockers may prevent new-onset diabetes in obese patients with high blood pressure.

More Related Videos

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study

Published on: November 21, 2025

Related Experiment Videos

Last Updated: Jun 25, 2026

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study

Published on: November 21, 2025

Area of Science:

Endocrinology and Metabolism
Cardiovascular Science
Pharmacology

Context:

Obesity is a significant risk factor for hypertension.
Adipose tissue plays a crucial role in metabolic and cardiovascular regulation through the renin-angiotensin system.
Obesity-related metabolic dysfunction contributes to cardiovascular disease development.

Purpose:

To investigate the role of the renin-angiotensin system in obesity-associated hypertension and metabolic disorders.
To evaluate the efficacy of angiotensin receptor blockade in preventing new-onset diabetes in obese hypertensive patients.

Summary:

The renin-angiotensin system (RAS) molecules produced by adipose tissue contribute to metabolic and cardiovascular complications in obesity.
The CASE-J Study specifically examined the impact of angiotensin receptor blockade.
Results indicated that angiotensin receptor blockade is useful in preventing new-onset diabetes in obese hypertensive individuals.

Impact:

Highlights the link between obesity, hypertension, and diabetes.
Demonstrates a potential therapeutic strategy for managing metabolic complications in obese hypertensive patients.
Supports the role of targeting the renin-angiotensin system for cardiovascular and metabolic health in obesity.