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Published on: April 15, 2021
Coronary aneurysms
1Department of Cardiology, Central Clinical Hospital Ministry of Interior and Administration, Warszawa, Poland. anetagziut@poczta.onet.pl
Insights
Coronary aneurysms, abnormal artery dilations, affect up to 4.9% of patients. Management focuses on preventing blood clots and closing the aneurysm entry.
Area of Science:
- Cardiology
- Vascular Biology
Background:
- Coronary aneurysms are vascular anomalies affecting 0.15-4.9% of patients.
- Definitions vary, encompassing diffuse or localized dilations exceeding 150% of normal diameter.
- Most common in the right coronary artery, least in the left main coronary artery.
Purpose of the Study:
- To review the definitions, causes, and management of coronary aneurysms.
- To highlight the role of vascular wall pathology in aneurysm formation.
- To discuss therapeutic strategies for preventing complications.
Main Methods:
- Literature review of coronary aneurysm definitions and pathogenesis.
- Analysis of etiological factors including atherosclerosis and Kawasaki disease.
- Examination of clinical consequences and treatment approaches.
Main Results:
- Atherosclerosis is the primary cause in adults; Kawasaki disease in younger populations.
- Vascular media pathology is a key factor in aneurysm development.
- Common complications include thrombus formation, embolization, vasospasm, and vessel disruption.
Conclusions:
- Standardized definitions for coronary aneurysms are lacking.
- Effective management requires addressing thromboembolic risks and aneurysm closure.
- Understanding pathogenesis is crucial for optimal patient care.
Abstract:
Coronary aneurysms represent anomalies identified in 0.15-4.9% of patients undergoing coronary angiography. At present there is no uniform definition of this pathology. According to current definitions, the term "aneurysm" refers to both diffuse over 150% dilation of the largest diameter of a coronary artery, and limited spherical or saccular dilation. Aneurysms are observed most commonly in the right coronary artery, and least frequently in the left main coronary artery. It has been demonstrated that atherosclerosis is the main cause of these anomalies in adults, and Kawasaki disease in children and adolescents. However, regardless of the pathogenesis of the aneurysm, pathology of the media of the blood vessel plays a major role in its formation. The most prevalent consequence of aneurysms in the coronary arteries is formation of a thrombus with distal embolization, vasospasm or vessel disruption at the site of wall injury. Therefore, therapeutic management in this anomaly involves both the prevention of thromboembolic complications and percutaneous or surgical closure of the aneurysm entry.
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