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Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining
Published on: December 23, 2016
Measles studies in the macaque model
1Department of Virology, Erasmus MC, University Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands. r.deswart@erasmusmc.nl
Current Topics in Microbiology and Immunology
|February 11, 2009
Summary
The macaque model has been crucial for understanding measles virus, leading to live-attenuated vaccines. New recombinant measles virus strains enhance detection for improved vaccination and pathogenesis studies.
Area of Science:
- Virology
- Immunology
- Vaccinology
Background:
- Non-human primate models, particularly macaques, are foundational to measles research.
- Historical experiments in macaques identified measles virus and informed vaccine development.
- Macaque studies demonstrated measles virus attenuation, crucial for live-attenuated vaccine creation.
Purpose of the Study:
- To review the macaque model for measles research over the last 15 years.
- To focus on vaccination and immunopathogenesis studies in macaques.
- To highlight advancements in measles virus detection using recombinant strains.
Main Methods:
- Review of historical and recent macaque studies on measles virus infection.
- Analysis of vaccination and immunopathogenesis research in macaques.
- Application of a recombinant measles virus expressing enhanced green fluorescent protein (eGFP) for sensitive virus detection.
Main Results:
- Macaque models have historically contributed to understanding measles virus and vaccine development.
- Serial passage in macaques led to measles virus attenuation, forming the basis of current vaccines.
- Recombinant measles virus expressing eGFP significantly enhances virus detection sensitivity in animals.
Conclusions:
- The macaque model remains indispensable for measles virus research, including vaccine efficacy and pathogenesis.
- Advanced detection methods using recombinant measles virus open new avenues for studying measles vaccination and disease.
- Continued use of the macaque model with novel tools will deepen our understanding of measles.
