NMR studies of molecular complexes as a tool in drug design

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NMR studies of molecular complexes as a tool in drug design

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Myeloid cell leukemia-1 is an important apoptotic survival factor in triple-negative breast cancer.

Tumor vasculature is a key determinant for the efficiency of nanoparticle-mediated siRNA delivery.

'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737.

RNAi-based screening of the human kinome identifies Akt-cooperating kinases: a new approach to designing efficacious multitargeted kinase inhibitors.

Rational design of diflunisal analogues with reduced affinity for human serum albumin.

Structure of the N-terminal region of Haemophilus influenzae H10017: implications for function.

Synthetic Heparan Sulfate-like Oligosaccharides as Tools to Decipher Growth Factor Recognition.

A Novel Trigonal Prismatic Rhenium Complex of 2-Hydroxythiobenzhydrazide as a Potent and Selective Anticancer Agent.

Bifunctional Ionophores for Cuproptosis Activation: Dual Targeting of Copper and Fe-S Protein Homeostasis.

Lead Optimization of Quinoline-Coumarin KRAS mRNA G-Quadruplex Ligands: Discovery of Non-Quaternary Ammonium Analogs as Translation Inhibitors.

Accurate Identification of Covalently Ligandable Cysteines Using CCSite.

High-Resolution Relaxometry for Fragment Screening.

Iron(II) and Copper(II) Ions Modulating Binding Interaction of Sugar-Based Silatrane With DNA: Analytical and Theoretical Validation.

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