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Updated: Jun 25, 2026

Efficient Derivation of Human Neuronal Progenitors and Neurons from Pluripotent Human Embryonic Stem Cells with Small Molecule Induction

Efficient Derivation of Human Neuronal Progenitors and Neurons from Pluripotent Human Embryonic Stem Cells with Small Molecule Induction

Published on: October 28, 2011

Human ESC-derived neural rosettes and neural stem cell progression.

Y Elkabetz¹, L Studer

¹Developmental Biology Program, Division of Neurosurgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

Cold Spring Harbor Symposia on Quantitative Biology

|February 11, 2009

Summary

This summary is machine-generated.

Rosette-stage neural stem cells (R-NSCs) show remarkable plasticity, generating diverse neuron types unlike typical neural stem cells (NSCs). This discovery offers new avenues for regenerative medicine and understanding CNS development.

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Last Updated: Jun 25, 2026

Efficient Derivation of Human Neuronal Progenitors and Neurons from Pluripotent Human Embryonic Stem Cells with Small Molecule Induction

Efficient Derivation of Human Neuronal Progenitors and Neurons from Pluripotent Human Embryonic Stem Cells with Small Molecule Induction

Published on: October 28, 2011

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Published on: February 21, 2015

Feeder-free Derivation of Neural Crest Progenitor Cells from Human Pluripotent Stem Cells

Feeder-free Derivation of Neural Crest Progenitor Cells from Human Pluripotent Stem Cells

Published on: May 22, 2014

Area of Science:

Neuroscience
Stem Cell Biology
Developmental Biology

Background:

Neural stem cells (NSCs) self-renew and differentiate into neurons, astrocytes, and oligodendrocytes.
Traditional NSCs have limited capacity for generating specific neuron subtypes.
Human embryonic stem cell research revealed a novel NSC stage with broader neuronal potential.

Purpose of the Study:

To discuss the properties of rosette-stage NSCs (R-NSCs).
To contextualize R-NSCs within existing NSC biology.
To identify key questions for future R-NSC research.

Main Methods:

Characterization of R-NSC cytoarchitecture and gene expression.
Investigation of extrinsic growth requirements for R-NSCs.
Comparative analysis of R-NSCs against other NSC populations.

Main Results:

R-NSCs exhibit distinct cytoarchitecture and gene expression profiles.
R-NSCs demonstrate plasticity for generating a wide range of neuron types.
R-NSCs require specific extrinsic growth factors for their development.

Conclusions:

R-NSCs may represent a unique NSC population capable of generating the full diversity of the developing central nervous system (CNS).
R-NSCs hold significant implications for regenerative medicine and drug discovery.
Further research is needed to fully understand R-NSC potential and applications.