Related Experiment Videos
Planning posttherapeutic oncology surveillance visits based on individual risk
T Filleron1, A Barrett, O Ataman
1Unité de Biostatistique, CRLC Val d'Aurelle-Paul Lamarque, Montpellier cedex 5, France.
Abstract:
The main objective of posttherapeutic surveillance in oncology is to detect recurrent disease associated with treatment failure. Current follow-up schedules are easy to apply because they are planned on a regular basis (for instance, every 3 months) but do not take into account prognostic factors associated with time to failure. We propose a 2-stage strategy to individualize surveillance by first identifying prognostic factors for time to failure, then modeling cumulative risk or cumulative incidence to plan visits according to equal quantiles of risk or probability of failure, respectively. Using data from a clinical trial of radiotherapy in non-small cell lung cancer patients, we demonstrate how this method could improve the early detection of relapse.
Related Concept Videos
Planning Nursing Care I
Kidney Transplant III: Nursing Management
Cancer Survival Analysis
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...