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Updated: Jun 25, 2026
Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
Published on: April 12, 2024
Computer-aided measurements of pulmonary emphysema in chest multidetector-row spiral computed tomography: effect of
Florian F Behrendt1, Marco Das, Andreas H Mahnken
1Department of Diagnostic Radiology, University Hospital, RWTH-Aachen University, Aachen, Germany. behrendt@rad.rwth-aachen.de
Objective:
To evaluate the effect of different image reconstruction parameters on quantitative automated measurements of pulmonary emphysema in chest multidetector-row spiral computed tomography.
Materials And Methods:
Thirty patients with known emphysema underwent multidetector-row spiral computed tomography. Retrospective reconstruction with a soft tissue kernel (Siemens B20 at 1-mm, 2-mm, and 3-mm slices) and 4 alternative kernel grades (from smooth to sharp: Siemens B30, B40, B50, B60 at 1-mm slices) was performed. Total lung volume, emphysema volume (EV), 15th percentile density, and 4 EV clusters were quantified. Results were compared with those of standard algorithm B20/1-mm slices.
Results:
Differences in total lung volume were less than 0.2%. Alternative kernel grades resulted in a significantly increased average EV. The 15th percentile density showed a significant average difference for all alternative algorithms. The large emphysema cluster showed a significant change for reconstruction algorithms B50, B60, B20/2 mm and B20/3 mm.
Conclusions:
Pulmonary EV is significantly affected by different reconstruction algorithms.
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