Related Experiment Video
Updated: Jun 25, 2026

Unveiling Xenobiotic Transport and Effects in Isolated Mitochondria: Insights from Respirometric and Enzymatic Assays
Published on: March 7, 2025
Grapefruit juice and verapamil: a toxic cocktail
Unnikrishnan Pillai1, Jameel Muzaffar, Sandeep Sen
1Internal Medicine and the Medical Clinic, St. Mary's Health Center, St. Louis, MO 63117, USA. unnikrishnanpk@yahoo.com
Abstract:
The US public consumes grapefruit juice in large quantities, with 14% of the population drinking the juice at least weekly. Grapefruit juice is a well-documented inhibitor of the CYP3A4 isoenzyme, which is involved in the metabolism of over 50% of commonly prescribed drugs. Here we report an unusual case of verapamil toxicity in a 42-year-old female, which resulted from accidental ingestion of only three tablets of the sustained release preparation (120 mg each) over 24 hours which resulted in severe toxicity.
More Related Videos
Related Concept Videos
Pharmacokinetics: Drug–Food and Drug–Viral Interactions
Drug toxicity: Drug–Drug Interaction
Drug Toxicity: Overview
Pharmaceutical Poisoning: Treatment Strategies
Drug Toxicity: Risk factors
Drug Toxicity: Dose-Dependent Reactions

