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Related Experiment Videos

Substance P and primary afferent transmission.

M Otsuka, S Konishi, T Takahashi

    Advances in Biochemical Psychopharmacology
    |January 1, 1976
    PubMed
    Summary

    Substance P, a neuropeptide, excites spinal motoneurons in newborn rats. This action is blocked by Lioresal, suggesting Substance P acts as a primary afferent neurotransmitter.

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    Area of Science:

    • Neuroscience
    • Neuropharmacology
    • Spinal Cord Research

    Background:

    • Substance P is a neuropeptide implicated in pain and sensory transmission.
    • Primary afferent fibers play a crucial role in transmitting sensory information to the spinal cord.

    Purpose of the Study:

    • To investigate the role of Substance P as a neurotransmitter in the spinal cord.
    • To examine the effects of Substance P on spinal motoneurons and reflexes.

    Main Methods:

    • Electrophysiological recordings in newborn rat spinal cord.
    • Administration of Substance P and Lioresal.
    • Analysis of Substance P localization in neural tissues.

    Main Results:

    • Substance P demonstrated a potent excitatory effect on spinal motoneurons.
    • Lioresal specifically antagonized the excitatory action of Substance P.
    • Substance P was found to be concentrated in dorsal roots and the dorsal horn.

    Conclusions:

    • Substance P is likely an excitatory neurotransmitter released by primary afferent fibers.
    • Lioresal's antagonism suggests a role in modulating primary afferent transmission.

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