Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The relationship between job crafting and work engagement among nurses in China: A latent profile analysis.

Nursing open·2024

Same author

Risk perception and quality of working life of nurses in infectious disease department in China: The chain-mediating effects of psychological resilience and social support.

Nursing open·2024

Same author

Insomnia and anxiety among COVID-19 patients in China: the chain mediating effect of psychological capital and self-esteem.

BMC nursing·2024

Same author

The biosafety incident response competence scale for clinical nursing staff: a development and validation study.

BMC nursing·2024

Same author

[Metabolic mechanism and intervention strategy of atrial fibrillation in the elderly].

Sheng li xue bao : [Acta physiologica Sinica]·2023

Same author

The relationship between role ambiguity and anxiety in intensive care unit nurses: The mediating role of emotional intelligence.

Intensive & critical care nursing·2023

Search research articles

Related Experiment Video

Updated: Jun 25, 2026

Generation of Murine Cardiac Pacemaker Cell Aggregates Based on ES-Cell-Programming in Combination with Myh6-Promoter-Selection

Generation of Murine Cardiac Pacemaker Cell Aggregates Based on ES-Cell-Programming in Combination with Myh6-Promoter-Selection

Published on: February 17, 2015

Using embryonic stem cells to form a biological pacemaker via tissue engineering technology.

Dong-Bo Ou¹, Hong-Juan Lang, Rui Chen

¹Department of Cardiology and Arrhythmologic Center, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology

|February 11, 2009

Summary

This summary is machine-generated.

Tissue engineering using embryonic stem cells (ESCs) offers a promising strategy for developing biological pacemakers. This approach aims to overcome challenges associated with ESCs for cardiac pacing applications.

More Related Videos

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

Published on: January 18, 2019

Maturation of Human Stem Cell-derived Cardiomyocytes in Biowires Using Electrical Stimulation

Maturation of Human Stem Cell-derived Cardiomyocytes in Biowires Using Electrical Stimulation

Published on: May 6, 2017

Related Experiment Videos

Last Updated: Jun 25, 2026

Generation of Murine Cardiac Pacemaker Cell Aggregates Based on ES-Cell-Programming in Combination with Myh6-Promoter-Selection

Generation of Murine Cardiac Pacemaker Cell Aggregates Based on ES-Cell-Programming in Combination with Myh6-Promoter-Selection

Published on: February 17, 2015

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

Published on: January 18, 2019

Maturation of Human Stem Cell-derived Cardiomyocytes in Biowires Using Electrical Stimulation

Maturation of Human Stem Cell-derived Cardiomyocytes in Biowires Using Electrical Stimulation

Published on: May 6, 2017

Area of Science:

Biomedical Engineering
Regenerative Medicine
Cardiology

Background:

Biological pacemakers are pursued via gene and cell-based methods.
Embryonic stem cells (ESCs) offer potential for biological pacemakers but face differentiation control and safety challenges (neoplasia, proarrhythmia, immunogenicity).

Purpose of the Study:

To explore tissue-engineering techniques for precise control of ESC differentiation and construct formation for biological pacemakers.
To investigate the potential of ESCs as a source for tissue-engineered cardiac pacing solutions.

Main Methods:

Utilizing tissue-engineering to precisely control multicellular aggregates composed of ESC-derived pacemaker cells, supporting cells, and matrices.
Leveraging the self-renewal, proliferation, and differentiation capabilities of ESCs.

Main Results:

Tissue engineering enables controlled architecture and functional properties of ESC-derived constructs.
Combined cell-matrix interactions can potentially reproduce pacemaker properties and induce rhythmic activity.

Conclusions:

Tissue-engineering combined with ESCs presents a viable strategy for creating functional biological pacemakers.
This approach may overcome current limitations and achieve the goal of ESC-based cardiac pacing.