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Updated: Jun 25, 2026
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Use of Magnetic Resonance Imaging and Biopsy Data to Guide Sampling Procedures for Prostate Cancer Biobanking
Published on: October 10, 2019
Central quadrant procurement of radical prostatectomy specimens
Carl Morrison1, Richard Cheney, Candace S Johnson
1Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA. carl.morrison@roswellpark.org
The Prostate
|February 11, 2009
Summary
Researchers developed a simplified method to collect gram amounts of fresh prostate cancer tissue from radical prostatectomy specimens. This technique ensures high-quality tissue yield without affecting cancer grading or staging, aiding prostate cancer research.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- High-quality prostate tissue is crucial for prostate cancer research.
- Current procurement methods often fail to yield sufficient tissue or are difficult to replicate.
- Whole organ processing by pathology departments hinders tissue procurement for research.
Purpose of the Study:
- To present a simplified, reproducible model for obtaining gram quantities of fresh prostate tissue.
- To ensure the procured tissue is of high quality and relevant to prostate cancer research.
- To overcome limitations of existing tissue procurement methods.
Main Methods:
- A simplified procurement protocol was developed for radical prostatectomy specimens.
- The protocol requires minimal specialized processing.
- The impact on Gleason grade, tumor stage, and margin status was assessed.
Main Results:
- The simplified model consistently yields gram amounts of fresh prostate tissue.
- A high percentage of procured samples contain cancer tissue.
- The method does not negatively impact Gleason grade, tumor stage, or margin status.
Conclusions:
- A simplified prostate tissue procurement model effectively provides high-quality, cancer-containing tissue.
- This method is reproducible and minimally invasive, supporting prostate cancer research.
- The protocol facilitates the consistent acquisition of research-grade prostate tissue.
