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Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Larynx01:21

Larynx

The human larynx, often referred to as the voice box, is an intricate organ located in the neck. It serves as a pathway for air to enter the lungs during respiration and is an essential component of voice production.
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids, corniculates, and...
Chronic Obstructive Pulmonary Disease01:24

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations01:19

Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations

Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet cell...
Chronic Pharyngitis01:23

Chronic Pharyngitis

Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:

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Related Experiment Video

Updated: Jun 25, 2026

Machine Learning-Based Cough Tone Classification: Diagnostic Exploration of Chronic Obstructive Pulmonary Disease and Respiratory Tract Infections
06:22

Machine Learning-Based Cough Tone Classification: Diagnostic Exploration of Chronic Obstructive Pulmonary Disease and Respiratory Tract Infections

Published on: September 19, 2025

Characterization of laryngeal dysfunction in chronic persistent cough.

Nicole M Ryan1, Peter G Gibson

  • 1Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, University of Newcastle, Newcastle, 2308, NSW, Australia. nicole.ryan@newcastle.edu

The Laryngoscope
|February 11, 2009
PubMed
Summary

Laryngeal dysfunction, including paradoxical vocal cord movement, is common in chronic cough and linked to reduced quality of life. This condition may be treated by speech language therapy.

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Methods for Detecting Cough and Airway Inflammation in Mice
04:33

Methods for Detecting Cough and Airway Inflammation in Mice

Published on: August 2, 2024

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Last Updated: Jun 25, 2026

Machine Learning-Based Cough Tone Classification: Diagnostic Exploration of Chronic Obstructive Pulmonary Disease and Respiratory Tract Infections
06:22

Machine Learning-Based Cough Tone Classification: Diagnostic Exploration of Chronic Obstructive Pulmonary Disease and Respiratory Tract Infections

Published on: September 19, 2025

Methods for Detecting Cough and Airway Inflammation in Mice
04:33

Methods for Detecting Cough and Airway Inflammation in Mice

Published on: August 2, 2024

Area of Science:

  • Otolaryngology
  • Pulmonology
  • Speech-Language Pathology

Background:

  • Laryngeal symptoms are increasingly recognized in chronic persistent cough, potentially due to sensory hyperresponsiveness.
  • The motor consequences of sensory activation and the role of laryngeal dysfunction in chronic cough require further investigation.
  • Speech pathology treatment efficacy suggests laryngeal involvement in chronic cough.

Purpose of the Study:

  • To investigate the relationship between cough reflex sensitivity and laryngeal dysfunction in chronic cough patients.
  • To assess paradoxical vocal cord movement (PVCM) and extrathoracic airway hyperresponsiveness in relation to chronic cough.
  • To evaluate the impact of laryngeal dysfunction on quality of life in chronic cough.

Main Methods:

  • A cross-sectional case-control study comparing 25 adults with chronic persistent cough and 11 healthy controls.
  • Assessment included cough-specific quality of life questionnaire, hypertonic saline provocation for airway hyperresponsiveness, capsaicin challenge for cough reflex sensitivity, and fiberoptic laryngoscopy for PVCM.
  • Data were analyzed to determine the prevalence and characteristics of laryngeal dysfunction in chronic cough.

Main Results:

  • Laryngeal dysfunction was prevalent in chronic cough patients, with 56% exhibiting paradoxical vocal cord movement (PVCM).
  • PVCM was associated with cough reflex hypersensitivity, impaired quality of life, reduced inspiratory airflows, and significant extrathoracic airway hyperresponsiveness.
  • These findings indicate a strong link between laryngeal dysfunction and the pathophysiology of chronic cough.

Conclusions:

  • Laryngeal dysfunction, manifesting as PVCM and extrathoracic airway hyperresponsiveness, is common in chronic cough.
  • Laryngeal dysfunction significantly impacts quality of life for individuals with chronic cough.
  • Laryngeal hypersensitivity may be a key mechanism in chronic cough, potentially responsive to speech language therapy.