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Published on: January 28, 2019

A 4-year study on clinical characteristics of children hospitalized with rotavirus gastroenteritis

Stefanie Wildi-Runge1, Simone Allemann, Urs B Schaad

  • 1University Children's Hospital (UKBB), P.O. Box, 4005 Basel, Switzerland.

European Journal of Pediatrics
|February 12, 2009
PubMed

Insights

Rotavirus gastroenteritis (RVGE) significantly burdens young children, necessitating hospitalization for many. This study highlights the substantial impact of RVGE on children under three, informing vaccination strategies.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Rotavirus (RV) is a leading cause of severe gastroenteritis (GE) in children.
  • New RV vaccines necessitate updated data on disease burden for effective immunization strategies.

Purpose of the Study:

  • To assess the burden of rotavirus gastroenteritis (RVGE) in hospitalized children.
  • To provide data relevant to RV immunization strategies.

Main Methods:

  • Retrospective review of medical records for children hospitalized with RV infection (July 2002-March 2006).
  • Data extraction included RV antigen test results, hospitalization reason, demographics, disease severity (Vesikari score), and treatment.
  • Population data from the Federal Office of Statistics used for incidence calculations.

Main Results:

  • 608 hospitalizations (607 children) due to RVGE identified; 89% were primary admissions.
  • Cumulative incidence of RVGE was 26.7/1,000 children <3 years; 94% of hospitalizations were in children <3 years.
  • Median hospital stay was 4 days; 70% received intravenous fluids, 24% nasogastric rehydration.

Conclusions:

  • Rotavirus gastroenteritis imposes a substantial burden on pediatric healthcare systems.
  • An estimated 1 in 37 children under 3 years are hospitalized for RVGE.
  • Findings underscore the importance of RV vaccination for reducing childhood hospitalizations.

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