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Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
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From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes T&#252;6028
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MapsiDB: an integrated web database for type I polyketide synthases.

Hongseok Tae1, Jae Kyung Sohng, Kiejung Park

  • 1SmallSoft Co, Ltd, Jang-Dong 59-5, Yusung-Gu, Daejeon 305-343, South Korea. mbio94@naver.com

Bioprocess and Biosystems Engineering
|February 12, 2009
PubMed
Summary
This summary is machine-generated.

MapsiDB is a new database for polyketide and polyketide synthase (PKS) data. This resource aids researchers by organizing diverse biological and genomic information for polyketide discovery.

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Area of Science:

  • Biochemistry
  • Bioinformatics
  • Genomics

Background:

  • Polyketides exhibit diverse biological activities, including antibiotic, antitumor, and agrochemical properties.
  • Polyketides are synthesized by polyketide synthases (PKSs) from carboxylic acid precursors.
  • The increasing volume of polyketide data necessitates a centralized management system.

Purpose of the Study:

  • To develop an integrated web database for managing data on type I polyketides and their associated PKSs.
  • To provide researchers with easy access to comprehensive polyketide and PKS information.
  • To facilitate data contribution from the research community.

Main Methods:

  • Collected polyketide data from scientific journals and online resources.
  • Processed and organized data using analysis programs.
  • Developed web interfaces for database construction and user access.

Main Results:

  • Created MapsiDB, an integrated web database for type I polyketides and PKSs.
  • Included data on domain and module composition and related genome information.
  • Enabled researchers to easily add and retrieve polyketide data.

Conclusions:

  • MapsiDB serves as a valuable resource for polyketide researchers.
  • The database facilitates the management and accessibility of complex polyketide and PKS data.
  • Centralized data management supports future discoveries in polyketide research.