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Updated: Jun 25, 2026

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Published on: August 25, 2023
Membranoproliferative glomerulonephritis associated with a mutation in Wilms' tumour suppressor gene 1
Detlef Bockenhauer1, William van't Hoff, Gil Chernin
1Nephrology, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, WC1N 3JH, UK. Detlef.Bockenhauer@nhs.net
Abstract:
Wilms' tumour suppressor gene 1 (WT1) encodes a transcription factor required for normal development of the genitourinary system. In the kidney, mutations in WT1 can cause diffuse mesangial sclerosis or focal segmental glomerulosclerosis. Here, we report on a girl with a mutation in WT1, who developed membranoproliferative glomerulonephritis (MPGN) 3 years after completion of treatment for Wilms' tumour. This finding extends the spectrum of glomerular disease seen with WT1 mutations and could have implications for the screening of children with MPGN.
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