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Published on: April 9, 2019
S100beta protein expression: gender- and age-related daily changes
M I Nogueira1, S Y Abbas, L G M Campos
1Department of Biology, Center for Neural Science, New York University, 100 Washington Square East, New York, NY 10003, USA. minog@usp.br
Neurochemical Research
|February 12, 2009
Summary
The brain protein S100beta exhibits daily rhythms in expression, with opposite cycles in male and female rats. These findings highlight potential gender differences and daily variations in S100beta levels, important for its use as a biomarker.
Area of Science:
- Neuroscience
- Biochemistry
- Chronobiology
Background:
- S100beta is a glial protein influencing neuronal development, stability, and plasticity.
- Its role in regulating neuronal morphology suggests potential daily and gender-specific variations in the brain.
Purpose of the Study:
- To investigate daily rhythms and gender differences in brain S100beta expression.
- To assess the implications of these variations for S100beta's function as a biomarker.
Main Methods:
- Scintillation counting and morphometric analysis of S100beta immunoreactivity in adult female and male rats.
- Comparative analysis using female CD-21 and S100beta knockout mice.
Main Results:
- S100beta expression displayed distinct daily rhythms in both female and male rats.
- Opposite expression cycles were observed: females peaked at 5:00 h (rest phase), males at 21:00 h (activity phase).
Conclusions:
- Daily rhythms and opposite gender-specific cycles of S100beta exist in the rat brain.
- These findings necessitate consideration of time of day and gender when interpreting S100beta levels as a biomarker for neurological conditions.
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