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Effects of hemodialysis on profound memory deficits in renal insufficiency due to multiple myeloma: a case study

Jane M Plagge1, James E Clay, Robin L Redwine

  • 1Pacific University, Forest Grove, and Oregon State Hospital, Salem, Oregon, USA. janeplagge@pacificu.edu

Applied Neuropsychology
|February 12, 2009
PubMed

Insights

Hemodialysis can improve neurocognitive function in multiple myeloma patients with renal failure. This case study shows significant memory and visuospatial gains with hemodialysis treatment.

Area of Science:

  • Neuroscience
  • Oncology
  • Nephrology

Background:

  • Multiple myeloma can cause neurocognitive deficits, particularly in younger patients.
  • Renal failure in multiple myeloma patients may lead to transient cognitive impairments.
  • Existing research suggests hemodialysis may improve these deficits.

Observation:

  • A complex case involving a multiple myeloma patient with renal insufficiency, seizure disorder, and schizophrenia was studied.
  • The patient experienced significant improvements in memory and visuospatial function.
  • These improvements were observed with both short-term and long-term hemodialysis administration.

Findings:

  • Memory impairments resolved within weeks of initiating hemodialysis.
  • Continued hemodialysis led to neurocognitive function in the superior range for some areas.
  • Overall cognitive improvement exceeded three standard deviations.

Implications:

  • Hemodialysis may be a viable treatment to improve neurocognitive function in select multiple myeloma patients.
  • Clinicians should consider hemodialysis for patients with multiple myeloma and associated cognitive deficits.
  • Further research is recommended to explore the broader application of hemodialysis in managing multiple myeloma-related neurocognitive dysfunction.

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