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Updated: Jun 25, 2026
Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
Published on: January 12, 2022
[Comparison of spectral- and time-domain OCT in regard of the automatic detection of central retinal thickness]
S C Beutelspacher1, J M Schmidbauer
1Augenklinik, Klinikum Nürnberg, Prof. Ernst-Nathan-Strasse 1, Nürnberg. sven.beutelspacher@klinikum-nuernberg.de
Background:
The aim of this study was to compare macular thickness measurements obtained from time-domain optical coherence tomography (OCT) and spectral-domain OCT to evaluate their agreement.
Materials And Methods:
Fifty randomly assigned subjects were included. Twenty-five were male, twenty-five female. In all cases both eyes were measured. Serial measurements were obtained from time-domain (StratusOCT, Zeiss) and spectral-domain OCT (Heidelberg Engineering, Germany). Total and regional macular thicknesses were obtained from both machines. Their agreement was estimated by Bland Altman plots.
Results:
The foveal and total macular thicknesses measured by 3D OCT were significantly greater than those measured by StratusOCT (p < 0.001).
Conclusions:
While both time-domain and spectral-domain OCTs are reliable for macular thickness measurements, spectral-domain OCT delivers significantly higher values for macular thickness compared to the time-domain OCT. Macular measurements obtained from the two OCT systems may not be used interchangeably.
