Related Experiment Video

Updated: Jun 25, 2026

A Bedside, Single Burr Hole Approach to Multimodality Monitoring in Severe Brain Injury
06:18

A Bedside, Single Burr Hole Approach to Multimodality Monitoring in Severe Brain Injury

Published on: March 26, 2019

[Intracranial pressure monitoring in children with fulminant hepatic failure]

W S Paiva1, A F de Andrade, R L O Amorim

  • 1Servicio de Neurocirugía, Hospital das Clinicas, Facultad de Medicina, Universidad de São Paulo, Sao Paulo, Brazil. wellingsonpaiva@yahoo.com.br

Revista De Neurologia
|February 12, 2009
PubMed

Insights

Intracranial pressure (ICP) monitoring in children with acute liver failure helps manage high ICP. This intensive care approach is safe and effective for pediatric patients awaiting liver transplantation.

Area of Science:

  • Pediatric Critical Care Medicine
  • Hepatology
  • Neurosurgery

Background:

  • Fulminant hepatic failure in children can lead to intracranial hypertension.
  • Intracranial pressure (ICP) monitoring is crucial for managing these critical cases.
  • This study focuses on pediatric patients requiring intensive care and potential liver transplantation.

Purpose of the Study:

  • To evaluate the application and outcomes of ICP monitoring in children with fulminant hepatic failure.
  • To assess the safety and efficacy of ICP monitoring in this specific pediatric population.
  • To inform intensive care and transplantation management strategies.

Main Methods:

  • Retrospective analysis of 10 pediatric patients with acute liver failure.
  • Data collected included ICP transducer type, duration of monitoring, and complications.
  • Patients underwent ICP monitoring as part of their intensive care management.

Main Results:

  • Hepatitis A and B were the most common causes of liver failure.
  • Initial ICP ranged from 2 to 24 mmHg.
  • Seven patients died; four from intracranial hypertension and three from transplantation failure. One case of subdural hematoma was noted.

Conclusions:

  • ICP monitoring facilitates aggressive management of intracranial hypertension in pediatric acute liver failure.
  • The technique is applicable to children without requiring specific adaptations.
  • Effective ICP management is vital for improving outcomes in this high-risk group.
Abstract

More Related Videos

Intracranial Pressure Monitoring In Nontraumatic Intraventricular Hemorrhage Rodent Model08:18

Intracranial Pressure Monitoring In Nontraumatic Intraventricular Hemorrhage Rodent Model

Published on: February 8, 2022

A Detailed Protocol for Physiological Parameters Acquisition and Analysis in Neurosurgical Critical Patients05:01

A Detailed Protocol for Physiological Parameters Acquisition and Analysis in Neurosurgical Critical Patients

Published on: October 17, 2017

Related Concept Videos

Increased Intracranial Pressure l: Introduction01:14

Increased Intracranial Pressure l: Introduction

Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...
Increased Intracranial Pressure ll: Pathophysiology01:29

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...