Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A general approach to unraveling structural changes of food proteins using atomistic model-based SAXS.

Food chemistry·2026
Same author

Deciphering high density lipoprotein (HDL) structure-function: Detailed analysis of HDL subfractions reveals molecular differences leading to atherosclerosis risk.

International journal of biological macromolecules·2026
Same author

Solutions of Carboxymethylcellulose with Organic Counterions (I): The Influence of Counterion Properties on the Polymer Structure and Solubility.

Macromolecules·2026
Same author

Scattering from 'Babinet' particles (or not…): spherical particles made up of spheres and spherical particles with spherical voids.

Journal of applied crystallography·2026
Same author

The Importance of Being Imperfect: Structure and Function of Bacterial Amyloid.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

Antibiotic vesicles based on peptide-polymer complex coacervation.

Journal of colloid and interface science·2025
Same journal

Switching Site Selectivity in Alkoxyamine Hydration: From Lone-Pair Direction to Solvent Network Dominance.

Journal of the American Chemical Society·2026
Same journal

A Topotactic Leap: 2D Layers to 3D Large-Pore Zeolite.

Journal of the American Chemical Society·2026
Same journal

Enhanced Hydrogen Evolution over Single-Atom Catalysts via Electrostatic Polarization in Contact-electro-catalysis.

Journal of the American Chemical Society·2026
Same journal

Tumor Acidity-Activatable Ionizable Lipid Nanoparticles for Selective Oncolytic Therapy.

Journal of the American Chemical Society·2026
Same journal

Alternating Magnetic Field Promotes Ammonia Cracking by Disrupting the Sabatier Limitation of Ruthenium Catalytic Species.

Journal of the American Chemical Society·2026
Same journal

Bulk Ferromagnetic Icosahedral Quasicrystals without Rapid Quenching.

Journal of the American Chemical Society·2026
See all related articles

Related Experiment Video

Updated: Jun 25, 2026

Magnetic and Thermal-sensitive Poly(N-isopropylacrylamide)-based Microgels for Magnetically Triggered Controlled Release
08:39

Magnetic and Thermal-sensitive Poly(N-isopropylacrylamide)-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

Temperature sensitive copolymer microgels with nanophase separated structure.

Martina Keerl1, Jan Skov Pedersen, Walter Richtering

  • 1Physical Chemistry, RWTH Aachen University, Landoltweg 2, D-52056 Aachen, Germany.

Journal of the American Chemical Society
|February 12, 2009
PubMed
Summary
This summary is machine-generated.

This study reveals copolymer microgels with distinct N-isopropylacrylamide (PNIPAM) and N-isopropylmethacrylamide (PNIPMAM) regions. A new model shows these microgels exhibit phase-separated nanodomains at their transition temperature.

More Related Videos

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

Related Experiment Videos

Last Updated: Jun 25, 2026

Magnetic and Thermal-sensitive Poly(N-isopropylacrylamide)-based Microgels for Magnetically Triggered Controlled Release
08:39

Magnetic and Thermal-sensitive Poly(N-isopropylacrylamide)-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

Area of Science:

  • Polymer Science
  • Materials Science
  • Nanotechnology

Background:

  • Thermosensitive microgels are responsive polymer networks.
  • Copolymer microgels offer tunable properties by combining different monomers.
  • Understanding internal structure is key to controlling microgel behavior.

Purpose of the Study:

  • To analyze small-angle neutron scattering data from a thermosensitive copolymer microgel.
  • To develop and apply a new form factor model for microgel analysis.
  • To investigate the internal morphology of copolymer microgels at their transition temperature.

Main Methods:

  • Small-angle neutron scattering (SANS) experiments.
  • Development of a novel form factor model incorporating nanophase separation.
  • Analysis of scattering curves to determine internal structure.

Main Results:

  • SANS data revealed an exceptional scattering curve shape at the copolymer microgel's transition temperature.
  • A new form factor model accurately described the experimental data.
  • The model indicated a nanophase separated internal morphology within the microgel.
  • At the transition temperature, collapsed PNIPAM domains and swollen PNIPMAM regions were observed.

Conclusions:

  • The copolymer microgel exhibits a unique internal structure with distinct, phase-separated domains.
  • The developed form factor model is effective for characterizing complex microgel morphologies.
  • One-pot synthesis can yield sophisticated materials with nanoscale phase separation.