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Pharmacogenomics: Identification of New Drug Targets

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

Pharmacogenetics and Pharmacogenomics: Overview

Pharmacogenetics and Pharmacogenomics: Overview

Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...

Drug Discovery: Overview

Drug Discovery: Overview

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Related Experiment Video

Updated: Jun 25, 2026

Cost-Efficient Transcriptomic-Based Drug Screening

Cost-Efficient Transcriptomic-Based Drug Screening

Published on: February 23, 2024

Integrative genomics and drug development.

Pek Y Lum¹, Jonathan M J Derry, Eric E Schadt

¹Department of Genetics, Rosetta Inpharmatics, LLC, 401 Terry Avenue North, Seattle, WA 98109, USA.

Pharmacogenomics

|February 12, 2009

Summary

The pharmaceutical industry needs better drug discovery methods. An integrated approach using organism-wide phenotyping, genomics, and modeling can improve success rates for new medicines.

Area of Science:

Pharmacology
Genomics
Systems Biology

Background:

The pharmaceutical industry struggles with high drug candidate failure rates in clinical development.
There is a critical need for innovative approaches to disease mechanism study and drug discovery.

Purpose of the Study:

To advocate for an integrated, organism-wide approach to drug discovery.
To leverage detailed phenotyping, high-throughput genomics, and mathematical modeling for improved drug development.

Main Methods:

Utilizing systematic genetic perturbations within populations to map molecular interactions.
Integrating detailed phenotyping and high-throughput genomic data.
Employing mathematical modeling to understand molecular and physiological states.

Related Experiment Videos

Last Updated: Jun 25, 2026

Cost-Efficient Transcriptomic-Based Drug Screening

Cost-Efficient Transcriptomic-Based Drug Screening

Published on: February 23, 2024

Main Results:

Systematic genetic perturbations reveal structures of molecular networks and states.
Linking molecular states to physiological states provides insights into disease drivers.
This integrated approach facilitates a deeper understanding of disease mechanisms.

Conclusions:

An integrated, organism-wide strategy enhances the understanding of disease mechanisms.
This paradigm shift promises truly rational drug design with higher clinical success probability.
The approach leverages population genetic variations for network discovery.