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Related Concept Videos

Bone Cells and Tissue01:30

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...
Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...

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Related Experiment Video

Updated: Jun 25, 2026

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
06:47

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells

Published on: May 4, 2018

The periosteum as a cellular source for functional tissue engineering.

Emily J Arnsdorf1, Luis M Jones, Dennis R Carter

  • 1Bone and Joint R&D Center, VA Palo Alto Health Care System, Palo Alto, California, USA. emily.arnsdorf@gmail.com

Tissue Engineering. Part A
|February 12, 2009
PubMed
Summary
This summary is machine-generated.

Periosteum cells show potential for tissue engineering, differentiating into both bone and fat cells. This suggests periosteal fibroblasts may act as progenitor cells, simplifying future tissue regeneration applications.

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Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
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Use of Human Perivascular Stem Cells for Bone Regeneration
07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Cell Biology

Background:

  • The periosteum, a fibrous tissue rich in fibroblasts, osteoblasts, and progenitor cells, is a promising source for tissue engineering due to its accessibility and cellular regenerative capacity.
  • Understanding the matrix elaboration potential of periosteum-derived cells is crucial for their functional application in tissue regeneration.

Purpose of the Study:

  • To investigate the differentiation potential of primary periosteum-derived cells under adipogenic and osteogenic conditions.
  • To compare the commitment propensity of periosteal cells with established fibroblast (NIH3T3) and osteoblast (MC3T3-E1) cell lines.

Main Methods:

  • Primary periosteum-derived cells were cultured under adipogenic and osteogenic conditions.
  • The differentiation potential was assessed by comparing gene expression and marker expression with NIH3T3 and MC3T3-E1 cell lines.

Main Results:

  • Heterogeneous periosteal cell populations and NIH3T3 fibroblasts exhibited similar potential to express both osteoblast-like and adipocyte-like markers.
  • This indicates that periosteal fibroblasts might possess progenitor-like capabilities, contributing to the tissue's multilineage potential.

Conclusions:

  • Expanded periosteal cultures may serve as a viable source for tissue engineering without the need for extensive cell enrichment or sorting.
  • Further research is warranted to fully elucidate the cellular sources and molecular mechanisms governing periosteal cell differentiation for regenerative applications.